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Prednisone & Weight Gain (The Studies) Many studies have been conducted to evaluate the side effect profile of prednisone and similar corticosteroid medications, namely prednisone and prednisolone. Here is a review of the studies and reviews that have been produced on the risk of weight gain with these drugs. There are several factors that are relevant in this study. In one of the studies in 2005 conducted by the United States Food and Drug Administration, the researchers noted that those using prednisone for the first time experienced a significant increase in weight. In another study conducted by the same researcher in 2008, the researchers noted more than a 3 fold increase in weight from the use of prednisone, an observation that is consistent with weight gain being greater with increasing use of this medication. These authors also point out that it is necessary to note that the study by Pekman et al., published in 1988, examined the first three months of use, and that it was not possible to adjust for weight gain due to the use of different medications. The other studies that are considered relevant do not differentiate the weight gain rate. In an analysis of 14 studies that included patients with nonabdominal obesity and were randomized to the use of prednisolone for 6 months or as compared to a control group, 12 published studies showed weight gain. This analysis revealed that 6 of the 12 studies demonstrated an increased weight gain rate of 1.3 pounds or more per month, and that 6 of those studies documented an increased weight gain rate of 4 pounds or greater. Thus, there are no studies that clearly suggest that the use of prednisone has a higher risk for weight gain. However, as indicated by Pekman et al. and by the investigators of another study done in 2007, the use of prednisone for at least 1 year and using different medications was associated with a significantly increased risk for obesity-related disorders such as: diabetes and increased risk for hypertension and coronary artery disease. If you have concerns about the use of prednisone and prednisolone, consider asking your doctor about the potential risks of weight gain, and discuss this with your provider. In Summary: Pre-exposure therapy (PEP) is a safe and effective technique to combat weight gain. However, use of this procedure must be undertaken with the advice of both a qualified dietician and a qualified medical professional. PEP is not an alternative treatment option when conventional or lifestyle weight-reduction strategies are ineffective. Related Article:

Legal, sustanon with test e

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